| First Author | Finotto S | Year | 2002 |
| Journal | Science | Volume | 295 |
| Issue | 5553 | Pages | 336-8 |
| PubMed ID | 11786643 | Mgi Jnum | J:73832 |
| Mgi Id | MGI:2156934 | Doi | 10.1126/science.1065544 |
| Citation | Finotto S, et al. (2002) Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 295(5553):336-8 |
| abstractText | Human asthma is associated with airway infiltration by T helper 2 (TH2) lymphocytes. We observed reduced expression of the TH1 transcription factor, T-bet, in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss of T-bet might be associated with asthma. Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4+ cells from T-bet knockout mice spontaneously demonstrated multiple physiological and inflammatory features characteristic of asthma. Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma. |
