| First Author | Juedes AE | Year | 2004 |
| Journal | J Exp Med | Volume | 199 |
| Issue | 8 | Pages | 1153-62 |
| PubMed ID | 15096540 | Mgi Jnum | J:121024 |
| Mgi Id | MGI:3709123 | Doi | 10.1084/jem.20031873 |
| Citation | Juedes AE, et al. (2004) T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes. J Exp Med 199(8):1153-62 |
| abstractText | The T-box transcription factor T-bet is known to control lineage commitment and interferon-gamma production by T helper 1 (Th1) CD4 lymphocytes. We report here that T-bet is essential for development of CD8 lymphocyte-dependent autoimmune diabetes (type 1 diabetes [T1D]) in the rat insulin promoter-lymphocytic choriomeningitis virus (LCMV) transgenic model for virally induced T1D. In the absence of T-bet, autoaggressive (anti-LCMV) CD8 lymphocytes were reduced in number and produced less IFN-gamma, but increased IL-2 compared with controls. Further analysis showed that T-bet intrinsically controls the generation, but not apoptosis, maintenance, or secondary expansion of antiviral effector/memory CD8 lymphocytes. This observation points toward a therapeutic opportunity for the treatment of T1D and other autoimmune disorders. |
