| First Author | Yoshida T | Year | 1996 |
| Journal | Immunity | Volume | 4 |
| Issue | 5 | Pages | 483-94 |
| PubMed ID | 8630733 | Mgi Jnum | J:33140 |
| Mgi Id | MGI:80621 | Doi | 10.1016/s1074-7613(00)80414-8 |
| Citation | Yoshida T, et al. (1996) Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice. Immunity 4(5):483-94 |
| abstractText | We generated interleukin-5 receptor alpha chain (IL-5R alpha)-deficient (IL-5R alpha(-/-)) mice by gene targeting. The IL-5R alpha(-/-) mice showed decreased numbers of B-l cells concomitant with low serum concentrations of IgM and IgG3. They showed no IL-5- induced enhancement of B cell responses to T-independent antigens. The number of alpha beta T cell receptor- positive thymocytes tended to decrease in 3-week-old IL-5R alpha(-/-) mice, returning to normal by 6 weeks of age. The IL-5R alpha(-/-) mice produced basal levels of eosinophils, while their bone marrow cells failed to form eosinophilic colonies in response to IL-5. Impaired eosinophilopoiesis in IL-5R alpha(-/-) mice enhanced the survival of Angiostrongylus cantonensis. These results indicate that IL-5-induced eosinophils serve as potent effector cells in the killing of Angiostrongylus cantonensis in mice. |
