| First Author | Nikawa T | Year | 2001 |
| Journal | Biochem Biophys Res Commun | Volume | 285 |
| Issue | 2 | Pages | 546-9 |
| PubMed ID | 11444878 | Mgi Jnum | J:70374 |
| Mgi Id | MGI:2137127 | Doi | 10.1006/bbrc.2001.5138 |
| Citation | Nikawa T, et al. (2001) Impaired vitamin A-mediated mucosal IgA response in IL-5 receptor-knockout mice. Biochem Biophys Res Commun 285(2):546-9 |
| abstractText | To clarify actions of vitamin A on mucosal immunity associated with interleukin-5 (IL-5), we examined effects of vitamin A on mucosal IgA level in IL-5 receptor alpha-chain-knockout (IL-5Ralpha(-/-)) mice. Daily supplementation of retinyl acetate (1 mg/mouse) increased Th2 cytokine levels and a number of their positive cells in the small intestinal mucosa of IL-5Ralpha(-/-) mice, as observed in wild-type or IL-5Ralpha(+/-) mice. Wild-type and heterozygous mice increased the IgA level and a number of IgA-containing cells in the mucosa in response to the vitamin A treatment, but not in IL-5Ralpha(-/-) mice. Retinyl acetate increased anti-cholera toxin (CT) IgA level in the mucosa of wild-type mice, improving their survival rate after an exposure to 0.4 mg of CT. However, retinyl acetate failed to induce resistance to CT toxicity in IL-5Ralpha(-/-) mice. Our results suggest that IL-5 may play an important role in an action of vitamin A on mucosal IgA system. Copyright 2001 Academic Press. |
