| First Author | Hanlon A | Year | 2005 |
| Journal | Immunology | Volume | 116 |
| Issue | 4 | Pages | 507-12 |
| PubMed ID | 16313364 | Mgi Jnum | J:106163 |
| Mgi Id | MGI:3617693 | Doi | 10.1111/j.1365-2567.2005.02252.x |
| Citation | Hanlon A, et al. (2005) Cbl-b differentially regulates activation-induced apoptosis in T helper 1 and T helper 2 cells. Immunology 116(4):507-12 |
| abstractText | We previously reported that ligation of CD3 induces antiapoptotic signals in T helper 2 (Th2) cells, and in contrast causes Th1 cells to undergo apoptosis. Here we show that Cbl-b is accountable for the unequal response, revealing a previously unknown cell-specific regulatory function for the molecule. Absence of Cbl-b resulted in resistance to activation-induced apoptosis in murine Th1 cells following CD3 ligation, akin to what is observed in Th2 cells containing Cbl-b. Concurrent with the apoptosis profile, CD3 ligation in the absence of Cbl-b induced raft mobilization and cytoskeletal rearrangement in Th1 cells. Despite their ability to signal from CD3, Th2 cells did not aggregate their rafts, providing an explanation for cell-specific activity of Cbl-b. |
