| First Author | Doisne JM | Year | 2009 |
| Journal | J Exp Med | Volume | 206 |
| Issue | 6 | Pages | 1365-78 |
| PubMed ID | 19451264 | Mgi Jnum | J:149449 |
| Mgi Id | MGI:3848555 | Doi | 10.1084/jem.20090127 |
| Citation | Doisne JM, et al. (2009) iNKT cell development is orchestrated by different branches of TGF-beta signaling. J Exp Med 206(6):1365-78 |
| abstractText | Invariant natural killer T (iNKT) cells constitute a distinct subset of T lymphocytes exhibiting important immune-regulatory functions. Although various steps of their differentiation have been well characterized, the factors controlling their development remain poorly documented. Here, we show that TGF-beta controls the differentiation program of iNKT cells. We demonstrate that TGF-beta signaling carefully and specifically orchestrates several steps of iNKT cell development. In vivo, this multifaceted role of TGF-beta involves the concerted action of different pathways of TGF-beta signaling. Whereas the Tif-1gamma branch controls lineage expansion, the Smad4 branch maintains the maturation stage that is initially repressed by a Tif-1gamma/Smad4-independent branch. Thus, these three different branches of TGF-beta signaling function in concert as complementary effectors, allowing TGF-beta to fine tune the iNKT cell differentiation program. |
