| First Author | Cui J | Year | 1997 |
| Journal | Science | Volume | 278 |
| Issue | 5343 | Pages | 1623-6 |
| PubMed ID | 9374462 | Mgi Jnum | J:76989 |
| Mgi Id | MGI:2180733 | Doi | 10.1126/science.278.5343.1623 |
| Citation | Cui J, et al. (1997) Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. Science 278(5343):1623-6 |
| abstractText | A lymphocyte subpopulation, the Valpha14 natural killer T (NKT) cells, expresses both NK1.1 and a single invariant T cell receptor encoded by the Valpha14 and Jalpha281 gene segments. Mice with a deletion of the Jalpha281 gene segment were found to exclusively lack this subpopulation. The Valpha14 NKT cell-deficient mice could no longer mediate the interleukin-12 (IL-12)-induced rejection of tumors. Although the antitumor effect of IL-12 was thought to be mediated through natural killer cells and T cells, Valpha14 NKT cells were found to be an essential target of IL-12, and they mediated their cytotoxicity by an NK-like effector mechanism after activation with IL-12. |
