| First Author | Chu X | Year | 2011 |
| Journal | Clin Immunol | Volume | 141 |
| Issue | 3 | Pages | 268-72 |
| PubMed ID | 21996456 | Mgi Jnum | J:178528 |
| Mgi Id | MGI:5299246 | Doi | 10.1016/j.clim.2011.09.003 |
| Citation | Chu X, et al. (2011) Islet allograft tolerance in the absence of invariant natural killer T cells. Clin Immunol 141(3):268-72 |
| abstractText | The invariant NKT cells are involved in both immunity and immune tolerance. However, their roles in transplant models remain controversial. We studied the role of NKT cells in the allograft response using two different strains of NKT deficient mice (CD1d-/- and Jalpha18-/- mice), and found that CD1d-/- and Jalpha18-/- mice rejected islet allografts with a similar kinetics as wild type B6 mice. Treatment of CD1d-/- and Jalpha18-/- mice with donor specific transfusion and anti-CD154 induced donor specific tolerance, which was identical to similarly treated wt B6 mice. The islet allograft tolerance requires Foxp3(+) Tregs. In the periphery, Foxp3(+) Tregs in CD1d-/-, Jalpha18-/-, and wt B6 mice were comparable both phenotypically and functionally. In addition, CD1d-/- and Jalpha18-/- CD4(+) T cells (non-Tregs) could be readily converted to Foxp3(+) Tregs by TGF-beta in vitro. Our data suggest that islet allograft tolerance can be successfully established without invariant NKT cells. |
