| First Author | King IL | Year | 2011 |
| Journal | Nat Immunol | Volume | 13 |
| Issue | 1 | Pages | 44-50 |
| PubMed ID | 22120118 | Mgi Jnum | J:178990 |
| Mgi Id | MGI:5300845 | Doi | 10.1038/ni.2172 |
| Citation | King IL, et al. (2011) Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner. Nat Immunol 13(1):44-50 |
| abstractText | Mouse invariant natural killer T cells (iNKT cells) provide cognate and noncognate help for lipid and protein-specific B cells, respectively. However, the long-term outcome for B cells after cognate help is provided by iNKT cells is unknown at present. Here we found that cognate iNKT cell help resulted in a B cell differentiation program characterized by extrafollicular plasmablasts, germinal-center formation, affinity maturation and a robust primary immunoglobulin G (IgG) antibody response that was uniquely dependent on iNKT cell-derived interleukin 21 (IL-21). However, cognate help from iNKT cells did not generate an enhanced humoral memory response. Thus, cognate iNKT cell help for lipid-specific B cells induces a unique signature that is a hybrid of classic T cell-dependent and T cell-independent type 2 B cell responses. |
