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Allele : Tg(TcraBDC2.5,TcrbBDC2.5)1Doi transgene insertion 1, Christophe Benoist
Primary Identifier  MGI:2181203 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
Strain of Origin  (C57BL/6 x SJL)F2 Is Recombinase  false
Is Wild Type  false
molecularNote  This transgene results from the coinjection of two constructs derived from diabetogenic T-cell clone BDC2.5. The Tcra construct contains a rearranged Tcra sequence (V alpha J alpha) that begins 20 bp 5' of the ATG site and ends 30 bp 3' of the splice donor sequence of J alpha 17. The 6.5 Tcrb construct contains rearranged Tcrb sequence (V beta D beta J beta) flanked by 2 kb of 5' regulatory sequences and 3.5 kb of 3' DNA containing the unrearranged J beta 1.3 to J beta 1.6 sequences, and precedes a 12 kb sequence containing the C beta 2 region.
  • mutations:
  • Insertion
  • synonyms:
  • Tg(TcraBDC2.5)2Doi,
  • Tg(TcrbBDC2.5)2Doi,
  • BDC2.5,
  • BDC2.5,
  • BDC-2.5/N TCR Tg,
  • BDC-2.5/N TCR Tg,
  • Tg(TcraBDC2.5)2Doi,
  • Tg(TcrbBDC2.5)2Doi
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1 Feature

Trail: Allele

Genome

2 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

7 Carried By

Trail: Allele

0 Driven By

155 Publication categories

Trail: Allele




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