| First Author | Beaudoin L | Year | 2002 |
| Journal | Immunity | Volume | 17 |
| Issue | 6 | Pages | 725-36 |
| PubMed ID | 12479819 | Mgi Jnum | J:132259 |
| Mgi Id | MGI:3775573 | Doi | 10.1016/s1074-7613(02)00473-9 |
| Citation | Beaudoin L, et al. (2002) NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic beta cells. Immunity 17(6):725-36 |
| abstractText | To determine the precise regulatory effect of NKT cells on CD4(+) T cells involved in autoimmune diabetes, we developed an in vivo model in which transferred naive transgenic T cells are stimulated by their antigen in the presence or absence of NKT cells or in the presence of another conventional transgenic alphabeta T cell. The presence of NKT cells did not block the initial activation and expansion of the CD4(+) T cells but did inhibit their IL-2 and IFN-gamma production and later proliferation, resulting in an anergic phenotype. These CD4(+) T cells did not induce significant insulitis and were unable to destroy the beta cells. Thus, NKT cells prevent alphabeta CD4 T cell differentiation into effector cells. |
