| First Author | Haldar M | Year | 2007 |
| Journal | Cancer Cell | Volume | 11 |
| Issue | 4 | Pages | 375-88 |
| PubMed ID | 17418413 | Mgi Jnum | J:120967 |
| Mgi Id | MGI:3708432 | Doi | 10.1016/j.ccr.2007.01.016 |
| Citation | Haldar M, et al. (2007) A conditional mouse model of synovial sarcoma: insights into a myogenic origin. Cancer Cell 11(4):375-88 |
| abstractText | Synovial sarcoma is an aggressive soft-tissue malignancy marked by a unique t(X;18) translocation leading to expression of a chimeric SYT-SSX fusion protein. We report here a mouse model of synovial sarcoma based on conditional expression of the human SYT-SSX2. Using this model, we have identified myoblasts as a potential source of synovial sarcoma. Remarkably, within the skeletal muscle lineage, while expression of the oncoprotein in immature myoblasts leads to induction of synovial sarcoma with 100% penetrance, its expression in more differentiated cells induces myopathy without tumor induction. We also show that early widespread expression of the fusion protein disrupts normal embryogenesis, causing lethality. |
