Primary Identifier | MGI:2180591 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Cckbr |
Transmission | Germline | Strain of Origin | 129S2/SvPas |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The insertion of a neomycin selection cassette deleted sequence encoding transmembrane domains V through VII, which are essential for structure. Radiolabeled binding experiments of cerbral plasma membranes isolated from homozygous mutant mice confirmed a lack of functional protein. |