| First Author | Nobs L | Year | 2014 |
| Journal | Glia | Volume | 62 |
| Issue | 5 | Pages | 829-39 |
| PubMed ID | 24550001 | Mgi Jnum | J:209138 |
| Mgi Id | MGI:5566547 | Doi | 10.1002/glia.22646 |
| Citation | Nobs L, et al. (2014) Stage-specific requirement for cyclin D1 in glial progenitor cells of the cerebral cortex. Glia 62(5):829-39 |
| abstractText | Despite the vast abundance of glial progenitor cells in the mouse brain parenchyma, little is known about the molecular mechanisms driving their proliferation in the adult. Here we unravel a critical role of the G1 cell cycle regulator cyclin D1 in controlling cell division of glial cells in the cortical grey matter. We detect cyclin D1 expression in Olig2-immunopositive (Olig2+) oligodendrocyte progenitor cells, as well as in Iba1+ microglia and S100beta+ astrocytes in cortices of 3-month-old mice. Analysis of cyclin D1-deficient mice reveals a cell and stage-specific molecular control of cell cycle progression in the various glial lineages. While proliferation of fast dividing Olig2+ cells at early postnatal stages becomes gradually dependent on cyclin D1, this particular G1 regulator is strictly required for the slow divisions of Olig2+/NG2+ oligodendrocyte progenitors in the adult cerebral cortex. Further, we find that the population of mature oligodendrocytes is markedly reduced in the absence of cyclin D1, leading to a significant decrease in the number of myelinated axons in both the prefrontal cortex and the corpus callosum of 8-month-old mutant mice. In contrast, the pool of Iba1+ cells is diminished already at postnatal day 3 in the absence of cyclin D1, while the number of S100beta+ astrocytes remains unchanged in the mutant. |
