| Primary Identifier | MGI:2180669 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Ctla4 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| description | Homozygous mutant mice accumulate T cell blasts in the lymph nodes and spleens which also infiltrate liver, heart, lung, and pancreas. Serum immunoglobulin is elevated, and the mice die by 3 to 4 weeks old. T cells proliferate when stimulated via T cell receptors, but are liable to Fas induced apoptosis (J:29652). |
| molecularNote | A neomycin selection gene replaced exon 2 and the 5' portion of exon 3. A lack of expression in homozygous mutant mice was demonstrated via fluorescence-activated cell sorting (FACS) analysis. |
