| First Author | Pandiyan P | Year | 2007 |
| Journal | J Immunol | Volume | 178 |
| Issue | 4 | Pages | 2132-40 |
| PubMed ID | 17277117 | Mgi Jnum | J:143993 |
| Mgi Id | MGI:3829567 | Doi | 10.4049/jimmunol.178.4.2132 |
| Citation | Pandiyan P, et al. (2007) High IFN-gamma production of individual CD8 T lymphocytes is controlled by CD152 (CTLA-4). J Immunol 178(4):2132-40 |
| abstractText | CD8 T cell expansion and cytokine production is needed to generate an effective defense against viral invasion of the host. These features of CD8 T lymphocytes are regulated, especially during primary responses, by positive and negative costimulation. We show in this study that surface expression of CD152 is highly up-regulated on activated CD8 T lymphocytes during primary immune responses, suggesting a prominent regulatory role. Indeed, production of the proinflammatory cytokine IFN-gamma, but not TNF-alpha, by CD8 T cells was inhibited by CD152 engagement. The inhibition was regulated independent of proliferation and IL-2 production, but dependent on the quality of the TCR signaling. We show that signals induced by CD152 on activated CD8 T lymphocytes reduce the frequency of IFN-gamma(high)-expressing cells. Our data also show that in activated CD8 T cells, the CD152-mediated inhibition of cytokine production is more pronounced than inhibition of their proliferation. |
