| First Author | Baratin M | Year | 2015 |
| Journal | Immunity | Volume | 42 |
| Issue | 4 | Pages | 627-39 |
| PubMed ID | 25862089 | Mgi Jnum | J:229701 |
| Mgi Id | MGI:5753017 | Doi | 10.1016/j.immuni.2015.03.003 |
| Citation | Baratin M, et al. (2015) Homeostatic NF-kappaB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance. Immunity 42(4):627-39 |
| abstractText | Migratory non-lymphoid tissue dendritic cells (NLT-DCs) transport antigens to lymph nodes (LNs) and are required for protective immune responses in the context of inflammation and to promote tolerance to self-antigens in steady-state. However, the molecular mechanisms that elicit steady-state NLT-DC maturation and migration are unknown. By comparing the transcriptome of NLT-DCs in the skin with their migratory counterparts in draining LNs, we have identified a novel NF-kappaB-regulated gene network specific to migratory DCs. We show that targeted deletion of IKKbeta in DCs, a major activator of NF-kappaB, prevents NLT-DC accumulation in LNs and compromises regulatory T cell conversion in vivo. This was associated with impaired tolerance and autoimmunity. NF-kappaB is generally considered the prototypical pro-inflammatory transcription factor, but this study describes a role for NF-kappaB signaling in DCs for immune homeostasis and tolerance that could have implications in autoimmune diseases and immunity. |
