| First Author | Roberts EW | Year | 2016 |
| Journal | Cancer Cell | Volume | 30 |
| Issue | 2 | Pages | 324-336 |
| PubMed ID | 27424807 | Mgi Jnum | J:234914 |
| Mgi Id | MGI:5792435 | Doi | 10.1016/j.ccell.2016.06.003 |
| Citation | Roberts EW, et al. (2016) Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma. Cancer Cell 30(2):324-36 |
| abstractText | Intratumoral dendritic cells (DC) bearing CD103 in mice or CD141 in humans drive intratumoral CD8(+) T cell activation. Using multiple strategies, we identified a critical role for these DC in trafficking tumor antigen to lymph nodes (LN), resulting in both direct CD8(+) T cell stimulation and antigen hand-off to resident myeloid cells. These effects all required CCR7. Live imaging demonstrated direct presentation to T cells in LN, and CCR7 loss specifically in these cells resulted in defective LN T cell priming and increased tumor outgrowth. CCR7 expression levels in human tumors correlate with signatures of CD141(+) DC, intratumoral T cells, and better clinical outcomes. This work identifies an ongoing pathway to T cell priming, which should be harnessed for tumor therapies. |
