|  Help  |  About  |  Contact Us

Allele : Sele<tm1Roml> selectin, endothelial cell; targeted mutation 1, Mark A Labow

Primary Identifier  MGI:2180868 Allele Type  Targeted
Attribute String  Null/knockout Gene  Sele
Transmission  Germline Strain of Origin  129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  The gene was disrupted by insertion of a neomycin resistance cassette into exon 1 after amino acid 162 of the LEC domain resulting in disruption of the protein's carbohydrate-binding domain. Northern blot analysis of lung from homozygous mutant animals detected several alternatively spliced mutant transcripts. Western blot, immunoprecipitation, and immunohistochemistry analyses were unable to detect gene expression in hearts from homozygous mutant animals.
  • mutations:
  • Insertion
  • synonyms:
  • E-selectin (-),
  • E-selectin (-)
Quick Links:
 
Quick Links:
 

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

10 Publication categories