| First Author | Thompson CL | Year | 2002 |
| Journal | Oncogene | Volume | 21 |
| Issue | 58 | Pages | 9043-56 |
| PubMed ID | 12483519 | Mgi Jnum | J:81235 |
| Mgi Id | MGI:2448398 | Doi | 10.1038/sj.onc.1205958 |
| Citation | Thompson CL, et al. (2002) Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock. Oncogene 21(58):9043-56 |
| abstractText | Blue light governs a number of cellular responses in bacteria, plants, and animals, including photoreactivation, plant development, and circadian photoentrainment. These activities are mediated by a family of highly conserved flavoproteins, the photolyase/cryptochrome family. Photolyase binds to UV photoproducts in DNA and repairs them in a process called photoreactivation in which blue light is used to initiate a cyclic electron transfer to break bonds and restore the integrity of DNA. Cryptochrome, which has a high degree of sequence identity to photolyase, works as the main circadian photoreceptor and as a component of the molecular clock in animals, including mammals, and regulates growth and development in plants. |
