| Primary Identifier | MGI:2181226 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Serpinf2 |
| Transmission | Germline | Strain of Origin | 129X1/SvJ |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A neomycin cassette replaced the entire coding region (exon 2 through the stop codon in exon 10). RT-PCR analaysis of kidney and liver tissue showed an absence of transcript in homozygous mutant mice. Western blot analyses of unactivated and activated plasma confirmed a lack of encoded protein in homozygous mice. Complex formation was undetectable by blotting analysis of plasma incubated with purified plasmin. |
