| First Author | Bellocchio L | Year | 2010 |
| Journal | Nat Neurosci | Volume | 13 |
| Issue | 3 | Pages | 281-3 |
| PubMed ID | 20139974 | Mgi Jnum | J:158629 |
| Mgi Id | MGI:4439246 | Doi | 10.1038/nn.2494 |
| Citation | Bellocchio L, et al. (2010) Bimodal control of stimulated food intake by the endocannabinoid system. Nat Neurosci 13(3):281-3 |
| abstractText | Activation of cannabinoid type-1 receptors (CB(1)) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood. Using combined genetic and pharmacological approaches in mice, we found that ventral striatal CB(1) receptors exerted a hypophagic action through inhibition of GABAergic transmission. Conversely, brain CB(1) receptors modulating excitatory transmission mediated the well-known orexigenic effects of cannabinoids. |
