| First Author | Martin-Blondel G | Year | 2015 |
| Journal | Eur J Immunol | Volume | 45 |
| Issue | 12 | Pages | 3302-12 |
| PubMed ID | 26358409 | Mgi Jnum | J:233736 |
| Mgi Id | MGI:5787908 | Doi | 10.1002/eji.201545632 |
| Citation | Martin-Blondel G, et al. (2015) Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the alpha4beta1-integrin. Eur J Immunol 45(12):3302-12 |
| abstractText | Although CD8 T cells are key players in neuroinflammation, little is known about their trafficking cues into the central nervous system (CNS). We used a murine model of CNS autoimmunity to define the molecules involved in cytotoxic CD8 T-cell migration into the CNS. Using a panel of mAbs, we here show that the alpha4beta1-integrin is essential for CD8 T-cell interaction with CNS endothelium. We also investigated which alpha4beta1-integrin ligands expressed by endothelial cells are implicated. The blockade of VCAM-1 did not protect against autoimmune encephalomyelitis, and only partly decreased the CD8(+) T-cell infiltration into the CNS. In addition, inhibition of junctional adhesion molecule-B expressed by CNS endothelial cells also decreases CD8 T-cell infiltration. CD8 T cells may use additional and possibly unidentified adhesion molecules to gain access to the CNS. |
