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Allele : Socs3<tm1Jni> suppressor of cytokine signaling 3; targeted mutation 1, James N Ihle
Primary Identifier  MGI:2181439 Allele Type  Targeted
Attribute String  Null/knockout Gene  Socs3
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
description  The embryonic lethality observed in homozygotes is rescued by tetraploid fusion with wild-type trophoblast stem cells (J:112739).
molecularNote  The entire coding region of the gene was replaced with a neomycin resistance cassette by homologous recombination. Homozygous embryos lacked gene expression as determined by immunofluorescent staining of erythroid progenitor cells.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • Socs3<tm11Jni>,
  • SOCS3<->,
  • SOCS-3 -,
  • Socs3<tm11Jni>,
  • SOCS3<->,
  • SOCS-3 -
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

16 Publication categories





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