| Primary Identifier | MGI:2181545 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Col2a1-Fgfr3/GH)ADor |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| description | Transgenic lines A and B were established and characterized. The phenotype of line A was less severe than that of line B, presumably due to a dosage effect of the transgene. |
| molecularNote | The transgene consists a mouse cDNA of Fgfr3 which harbors a dominant mutation found in human achondroplasia (G380R). This sequence is fused to human growth hormone gene with a deletion in exon 5 to provide additional splice and polyadenylation sites. Expression of the transgene is targeted to cartilage tissue by promoter and enhancer sequences derived from rat type II collagen gene. |
