| Primary Identifier | MGI:2181645 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Bace1 |
| Transmission | Germline | Strain of Origin | 129S5/SvEvBrd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | An expression cassette, containing a beta-galactosidase gene adjoined to an IRES as well as a neomycin resistance gene adjoined to a MC1 promoter, was inserted 2 nucleotides downstream of the start codon. The deleted sequence extended through the end of exon 1, a total of 165 nucleotides. Beta-secretase activity was undetected in brain homogenates and extracts of cortical cell cultures derived from homozygous mutant animals. |
