| First Author | Vishnivetskaya GB | Year | 2007 |
| Journal | Aggress Behav | Volume | 33 |
| Issue | 1 | Pages | 1-6 |
| PubMed ID | 17441000 | Mgi Jnum | J:127892 |
| Mgi Id | MGI:3765188 | Doi | 10.1002/ab.20161 |
| Citation | Vishnivetskaya GB, et al. (2007) Effect of MAO A deficiency on different kinds of aggression and social investigation in mice. Aggress Behav 33(1):1-6 |
| abstractText | Monoamine oxidase A (MAO A) degrades serotonin, dopamine and noradrenaline, factors critically involved in the regulation of aggression. Different kinds of aggression were investigated in Tg8, a transgenic mouse strain lacking a functional MAO A gene. MAO A-deficient mice differ from wild-type C3H/HeJ (C3H) in terms of showing higher territorial, predatory and isolation-induced aggression. Tg8 demonstrated shorter latencies to cricket killing and to the first attack after 6 weeks isolation than C3H mice. In the resident-intruder paradigm, MAO A-lacking mice were more aggressive than C3H when tested as intruders. In contrast to C3H, attack in Tg8 mice did not depend on different aggressiveness of intruders of BALB/c, A/Sn and C3H strains. Tg8 mice displayed no increase in aggression but demonstrated reduced social investigation towards anesthetized, as well as towards juvenile BALB/c males. Thus, MAO A deficiency in Tg8 mice is accompanied by increased expression of different kinds of aggression, as well as by disruption of normal pattern of social interaction. |
