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Allele : Csf2rb<tm1Mur> colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); targeted mutation 1, Richard Murray
Primary Identifier  MGI:2181261 Allele Type  Targeted
Attribute String  Null/knockout Gene  Csf2rb
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 4 was replaced by a neomycin cassette via homologous recombination. The deleted region encodes the third and fourth cysteine residues in the first repeat of the conserved motif of cytokine receptors. FACS analysis of bone marrow cells isolated from homozygous mutant mice showed a lack of a functional receptor. Additional FACS analysis showed that expression of the homologous protein, Csf3rb2, was intact.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • betac<->,
  • betac mutant,
  • betac<->,
  • betac mutant
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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