| First Author | Bachmann MF | Year | 1997 |
| Journal | Cell Immunol | Volume | 175 |
| Issue | 1 | Pages | 12-5 |
| PubMed ID | 9015183 | Mgi Jnum | J:37640 |
| Mgi Id | MGI:85031 | Doi | 10.1006/cimm.1996.1041 |
| Citation | Bachmann MF, et al. (1997) T-cell-independent antiviral B cell responses in CD45-deficient mice. Cell Immunol 175(1):12-5 |
| abstractText | CD45 is expressed on all B cells and has been reported to be essential for their B cell receptor mediated stimulation. The present study addressed T-cell-independent B cell responses in CD45-deficient mice using the glycoprotein (G) of vesicular stomatitis virus (VSV) as a model antigen. VSV-G exists in two forms exhibiting different degrees of repetitiveness. In mice, the two forms of VSV-G induce either a type 1 or a type 2 T-cell-independent B cell response. We found that CD45-deficient mice mounted T-cell-independent B cell responses to both forms of VSV-G. This demonstrates that the B cell receptor complex is able to generate a functional signal in the absence of CD45, provided the cross-linking stimulus is sufficiently strong. |
