| First Author | Fowler KJ | Year | 2004 |
| Journal | Reproduction | Volume | 127 |
| Issue | 3 | Pages | 367-77 |
| PubMed ID | 15016956 | Mgi Jnum | J:88942 |
| Mgi Id | MGI:3037475 | Doi | 10.1530/rep.1.00102 |
| Citation | Fowler KJ, et al. (2004) Centromere protein b-null mice display decreasing reproductive performance through successive generations of breeding due to diminishing endometrial glands. Reproduction 127(3):367-77 |
| abstractText | Centromere protein B is a highly conserved constitutive protein found at centromeres. Gene knockout studies in mice have unexpectedly identified Cenpb as a candidate gene involved in uterine function. The present study further explores the role of Cenpb in mice by intermating Cenpb-null mice over several generations. Breeding studies and analysis of uterine tissue indicate that Cenpb-null mice lose reproductive fitness over a number of generations due to a significant reduction in endometrial glands. These results suggest that Cenpb may play an important function in the short- and long-term maintenance of uterine integrity. |
