| Primary Identifier | MGI:2181754 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Pcsk6 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | 280 bp of the gene were replaced with a neomycin resistance cassette via homologous recombination. The deleted region encodes a catalytic serine essential for enzymatic activity. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of total brain mRNA using an antisense RNA probe encompassing the targeted region. |
