| First Author | Tzavara ET | Year | 2001 |
| Journal | Neuroreport | Volume | 12 |
| Issue | 7 | Pages | 1367-70 |
| PubMed ID | 11388413 | Mgi Jnum | J:103667 |
| Mgi Id | MGI:3610596 | Doi | 10.1097/00001756-200105250-00016 |
| Citation | Tzavara ET, et al. (2001) Effects of cannabinoids in Krox-24 targeted mice. Neuroreport 12(7):1367-70 |
| abstractText | Krox-24 is an immediate early gene encoding a zinc-finger transcription factor implicated in several adaptive responses, and its induction by cannabinoids has been reported. We used mice targeted in the Krox-24 gene to specifically dissect the role of this protein in the acute and chronic central actions of cannabinoids. We report here on the ability of cannabinoids to activate G-proteins and to inhibit adenylyl cyclase, and to elicit behavioral responses in wild-type and mutant mice. The behavioral parameters and the biochemical correlates of abstinence after delta9-THC withdrawal were evaluated. We show that Krox-24 is not involved in the acute analgesic effects of delta9-THC and in the SR precipitated delta9-THC withdrawal syndrome. |
