| First Author | Yoshida H | Year | 1998 |
| Journal | Immunity | Volume | 8 |
| Issue | 1 | Pages | 115-24 |
| PubMed ID | 9462517 | Mgi Jnum | J:236518 |
| Mgi Id | MGI:5806248 | Doi | 10.1016/s1074-7613(00)80464-1 |
| Citation | Yoshida H, et al. (1998) The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity 8(1):115-24 |
| abstractText | NF-ATc1 is a member of a family of genes that encodes the cytoplasmic component of the nuclear factor of activated T cells (NF-AT). In activated T cells, nuclear NF-AT binds to the promoter regions of multiple cytokine genes and induces their transcription. The role of NF-ATc1 was investigated in recombination activating gene-1 (RAG-1)-deficient blastocyst complementation assays using homozygous NF-ATc1-/- mutant ES cell lines. NF-ATc1-/-/RAG-1-/- chimeric mice showed reduced numbers of thymocytes and impaired proliferation of peripheral lymphocytes, but normal production of IL-2. Induction in vitro of Th2 responses, as demonstrated by a decrease in IL-4 and IL-6 production, was impaired in mutant T cells. These data indicate that NF-ATc1 plays roles in the development of T lymphocytes and in the differentiation of the Th2 response. |
