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Allele : Akt1<tm1Nhy> thymoma viral proto-oncogene 1; targeted mutation 1, Nissim Hay

Primary Identifier	MGI:2181580	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Akt1
Transmission	Germline	Strain of Origin	(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase	false	Is Wild Type	false

molecularNote

Exons 8 through 13 were replaced with a neomycin selection cassette. Encoded protein was not detected by Western blot analysis of fibroblasts isolated from homozygous mutant embryos.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
Akt1 KO,
Akt1<->,
Akt1<->,
Akt1 KO

earliestPublication:
Chen WS, et al. (2001) Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev 15(17):2203-8

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

34 Publication categories

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