| First Author | Nakagawa TY | Year | 1999 |
| Journal | Immunity | Volume | 10 |
| Issue | 2 | Pages | 207-17 |
| PubMed ID | 10072073 | Mgi Jnum | J:53399 |
| Mgi Id | MGI:1332381 | Doi | 10.1016/s1074-7613(00)80021-7 |
| Citation | Nakagawa TY, et al. (1999) Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. Immunity 10(2):207-17 |
| abstractText | Cathepsins have been implicated in the degradation of proteins destined for the MHC class II processing pathway and in the proteolytic removal of invariant chain (Ii), a critical regulator of MHC class II function. Mice lacking the lysosomal cysteine proteinase cathepsin S (catS) demonstrated a profound inhibition of Ii degradation in professional APC in vivo. A marked variation in the generation of MHC class II-bound Ii fragments and presentation of exogenous proteins was observed between B cells, dendritic cells, and macrophages lacking catS. CatS-deficient mice showed diminished susceptibility to collagen-induced arthritis, suggesting a potential therapeutic target for regulation of immune responsiveness. |
