| First Author | Lee SL | Year | 1995 |
| Journal | Science | Volume | 269 |
| Issue | 5223 | Pages | 532-5 |
| PubMed ID | 7624775 | Mgi Jnum | J:77686 |
| Mgi Id | MGI:2182310 | Doi | 10.1126/science.7624775 |
| Citation | Lee SL, et al. (1995) Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77). Science 269(5223):532-5 |
| abstractText | T cell hybridomas require the immediate-early gene NGFI-B (nur77) for T cell receptor (TCR)-mediated apoptosis, a model for negative selection of self-reactive T cells. TCR-mediated death was examined in mice bearing an NGFI-B loss-of-function mutation, either by administration of antibodies to CD3 (anti-CD3) or in two well-characterized transgenic models expressing self-reactive TCRs. Both the extent and the rate of thymocyte death were unimpaired. Anti-CD3-induced death was normal in CD4+ peripheral T cells, in which death is mediated predominantly by the Fas signaling pathway. Thus, no unique requirement for NGFI-B is observed for thymic or peripheral T cell death. |
