| Primary Identifier | MGI:2182336 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Col1a1-Bmpr1b)1Dic |
| Strain of Origin | (C57BL/6 x BALB/c)F1 | Is Recombinase | false |
| Is Wild Type | false |
| description | Expression of truncated protein in bone tissues of transgenic animals was verified by RT-PCR and Western blot analysis. Homozygous transgenic mice exhibit a 12% decrease in body weight and 5-9% decrease in bone mineral density (BMD). |
| molecularNote | A truncated Bmpr1b cDNA deleted for the kinase domain was placed under the control of 0.7 kb of enhancer/basal promoter sequences from Col1a1 to drive transgene expression in bone tissues. |
