| First Author | Rosen ED | Year | 2006 |
| Journal | Blood Cells Mol Dis | Volume | 36 |
| Issue | 2 | Pages | 131-4 |
| PubMed ID | 16524747 | Mgi Jnum | J:144138 |
| Mgi Id | MGI:3830160 | Doi | 10.1016/j.bcmd.2005.12.037 |
| Citation | Rosen ED, et al. (2006) Searching for hemostatic modifier genes affecting the phenotype of mice with very low levels of FVII. Blood Cells Mol Dis 36(2):131-4 |
| abstractText | FVII(tTA/-) mice are heterozygous for the FVII- null allele and a gene-targeted allele expressing very low levels of FVII. Approximately half the FVII(tTA/-) in a mixed C57Bl/6:129x1/SVJ background survive much longer than mice in a C57Bl/6 background, suggesting that genetic background affects the survival of mice expressing very low levels of FVII. A lineage of long-term surviving FVII(tTA/-) mice in a predominantly C57Bl/6 background was generated by selecting 16 weeks or older FVII(tTA/-) males and breeding them with C57Bl/6 FVII+/- females. It is postulated that these mice maintain 129x1/SVJ alleles at putative hemostatic modifier loci necessary for the survival of mice expressing very low levels of FVII. A SNP genomic scan was performed on DNA from long-term surviving FVII(tTA/-) mice. The scan identified 8 regions enriched for 129x1/SVJ sequences that might contain putative hemostatic modifier genes. |
