| First Author | Erb KJ | Year | 2003 |
| Journal | Infect Immun | Volume | 71 |
| Issue | 11 | Pages | 6641-7 |
| PubMed ID | 14573689 | Mgi Jnum | J:86279 |
| Mgi Id | MGI:2679187 | Doi | 10.1128/IAI.71.11.6641-6647.2003 |
| Citation | Erb KJ, et al. (2003) Mice deficient in nuclear factor of activated T-cell transcription factor c2 mount increased Th2 responses after infection with Nippostrongylus brasiliensis and decreased Th1 responses after mycobacterial infection. Infect Immun 71(11):6641-7 |
| abstractText | Infection of nuclear factor of activated T-cell transcription factor c2 (NFATc2)-deficient mice with the helminth Nippostrongylus brasiliensis led to a distinct increase in interleukin-4 (IL-4) and IL-5 protein synthesis by lymph node and spleen cells and to elevated serum immunoglobulin E (IgE) levels in comparison to those seen with infected control mice. While IL-4, IL-5, and IL-13 mRNA expression was also enhanced in lymph node cells from the lungs of infected NFATc2(-/-) mice, the number of T cells secreting Th2-type lymphokines remained the same in mice infected with N. brasiliensis. In contrast, lymphocytes from NFATc2-deficient mice infected with Mycobacterium bovis BCG secreted less gamma interferon than lymphocytes from infected control mice. These findings indicate that NFATc2 is an activator of Th1 responses and a suppressor of Th2 responses in vivo. |
