| First Author | Glud SZ | Year | 2005 |
| Journal | Blood | Volume | 106 |
| Issue | 10 | Pages | 3546-52 |
| PubMed ID | 16051745 | Mgi Jnum | J:106810 |
| Mgi Id | MGI:3619628 | Doi | 10.1182/blood-2005-02-0493 |
| Citation | Glud SZ, et al. (2005) A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus. Blood 106(10):3546-52 |
| abstractText | Nuclear factor of activated T cell (NFAT) transcription factors play a central role in differentiation, activation, and elimination of lymphocytes. We here report on the finding of provirus integration into the Nfatc3 locus in T-cell lymphomas induced by the murine lymphomagenic retrovirus SL3-3 and show that NFATc3 expression is repressed in these lymphomas. The provirus insertions are positioned close to the Nfatc3 promoter or a putative polyadenylated RNA (polyA) region. Furthermore, we demonstrate that NFATc3-deficient mice infected with SL3-3 develop T-cell lymphomas faster and with higher frequencies than wild-type mice or NFATc2-deficient mice. These results identify NFATc3 as a tumor suppressor for the development of murine T-cell lymphomas induced by the retrovirus SL3-3. |
