| First Author | Ranger AM | Year | 1998 |
| Journal | Immunity | Volume | 9 |
| Issue | 5 | Pages | 627-35 |
| PubMed ID | 9846484 | Mgi Jnum | J:51339 |
| Mgi Id | MGI:1315116 | Doi | 10.1016/s1074-7613(00)80660-3 |
| Citation | Ranger AM, et al. (1998) Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Immunity 9(5):627-35 |
| abstractText | Nuclear factor of activated T cells (NFAT) is a critical regulator of early gene transcription in response to TCR-mediated signals. Here, we show that mice lacking both NFATp and NFAT4 develop a profound lymphoproliferative disorder likely due to a lowered threshold for TCR signaling coupled with increased resistance to apoptosis secondary to defective FasL expression. NFAT mutant mice also have allergic blepharitis, interstitial pneumonitis, and a 10(3) to 10(4) fold increase in serum IgG1 and IgE levels, secondary to a dramatic and selective increase in Th2 cytokines. This phenotype may be ascribed to unopposed occupancy of the IL-4 promoter by NFATc. Our data demonstrate that lymphoid homeostasis and Th2 activation require a critical balance among NFAT family members. |
