| First Author | Barton K | Year | 1998 |
| Journal | Immunity | Volume | 9 |
| Issue | 4 | Pages | 555-63 |
| PubMed ID | 9806641 | Mgi Jnum | J:50627 |
| Mgi Id | MGI:1307022 | Doi | 10.1016/s1074-7613(00)80638-x |
| Citation | Barton K, et al. (1998) The Ets-1 transcription factor is required for the development of natural killer cells in mice. Immunity 9(4):555-63 |
| abstractText | In this report we have investigated the role of the Ets-1 transcription factor in the differentiation of the NK cell lineage in mice. Splenic NK cells express high levels of Ets-1. Ets-1-deficient mice produced by gene targeting developed mature erythrocytes, monocytes, neutrophils, and T and B lymphocytes. However, spleens from the Ets-1-deficient mice contained significantly reduced numbers of natural killer (NK) cells, and splenocytes from these mice lacked detectable cytolytic activity against NK cell targets in vitro. Moreover, unlike wild-type animals, Ets-1-deficient mice developed tumors following subcutaneous injection of NK-susceptible RMA-S cells. These NK cell defects could not be correlated with defects in the expression of IL-12, IL-15, and IL-18 or the IL-2 or IL-15 receptors. Thus, Ets-1 defines a novel transcriptional pathway that is required for the development of the NK cell lineage in mice. |
