| First Author | Stöckigt F | Year | 2017 |
| Journal | Biochem Biophys Res Commun | Volume | 493 |
| Issue | 1 | Pages | 604-610 |
| PubMed ID | 28867191 | Mgi Jnum | J:253999 |
| Mgi Id | MGI:6103575 | Doi | 10.1016/j.bbrc.2017.08.145 |
| Citation | Stockigt F, et al. (2017) Aging-related mitochondrial dysfunction facilitates the occurrence of serious arrhythmia after myocardial infarction. Biochem Biophys Res Commun 493(1):604-610 |
| abstractText | BACKGROUND: During aging a mosaic of normal cells and cells with mitochondrial deficiency develops in various tissues including the heart. Whether this contributes to higher susceptibility for arrhythmia following myocardial infarction (MI) is unknown. METHODS AND RESULTS: Myocardial cryoinfarction was performed in 12-month-old transgenic mice with accelerated accumulation of deletions in mitochondrial DNA. Occurrence and pathogenesis of arrhythmia was investigated after two weeks. Holter-ECG recordings revealed higher rates of premature ventricular complexes (incidence > 10/24 h: 100% vs. 20%; p = 0.048) and more severe spontaneous arrhythmia during stress test in mutant mice with MI as compared to control mice with MI. Mice with mitochondrial dysfunction exhibited longer spontaneous AV-blocks (467 +/- 26 ms vs. 377 +/- 24 ms; p = 0.013), an increased probability for induction of ventricular tachycardia during in vivo electrophysiological investigation (22% vs. 9%; p = 0.044), and a reduced conduction velocity in the infarct borderzone (38.5 +/- 0.5 cm/s vs. 55.3 +/- 0.9 cm/s; p = 0.001). Furthermore, mutant mice exhibited a significant reduction of the phospho-Cx43/Cx43 ratio in right (0.59 +/- 0.04 vs. 0.85 +/- 0.01; p = 0.027) and left ventricular myocardium (0.72 +/- 0.01 vs. 0.86 +/- 0.02; p = 0.023). CONCLUSIONS: Aging-related cardiac mosaic respiratory chain dysfunction facilitates the occurrence of spontaneous and inducible cardiac arrhythmia after myocardial infarction and is associated with slowing of electrical impulse propagation in the infarct borderzone. |
