| Primary Identifier | MGI:2182249 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Mdm2)1Snj |
| Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> |
| Is Recombinase | false | Is Wild Type | false |
| description | Transgenic animals express 4 times the amount of endogenous mRNA transcripts and exhibit and increased incidence of spontaneous tumorigenesis. Susceptibility to tumor formation appears to be influenced by gene dosage. One half of hemizogous transgenic animals succumb to neoplasia by 84 weeks of age compared to 61 weeks for homozygous transgenic animals. |
| molecularNote | The entire Mdm2 gene was used as the transgene. The transgene is under the control of the native promoter. |
