| First Author | Pommier Y | Year | 1998 |
| Journal | Biochim Biophys Acta | Volume | 1400 |
| Issue | 1-3 | Pages | 83-105 |
| PubMed ID | 9748515 | Mgi Jnum | J:171881 |
| Mgi Id | MGI:5000287 | Doi | 10.1016/s0167-4781(98)00129-8 |
| Citation | Pommier Y, et al. (1998) Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme. Biochim Biophys Acta 1400(1-3):83-105 |
| abstractText | DNA topoisomerase I is essential for cellular metabolism and survival. It is also the target of a novel class of anticancer drugs active against previously refractory solid tumors, the camptothecins. The present review describes the topoisomerase I catalytic mechanisms with particular emphasis on the cleavage complex that represents the enzyme's catalytic intermediate and the site of action for camptothecins. Roles of topoisomerase I in DNA replication, transcription and recombination are also reviewed. Because of the importance of topoisomerase I as a chemotherapeutic target, we review the mechanisms of action of camptothecins and the other topoisomerase I inhibitors identified to date. |
