| First Author | Konietzko U | Year | 1999 |
| Journal | EMBO J | Volume | 18 |
| Issue | 12 | Pages | 3359-69 |
| PubMed ID | 10369676 | Mgi Jnum | J:114209 |
| Mgi Id | MGI:3688496 | Doi | 10.1093/emboj/18.12.3359 |
| Citation | Konietzko U, et al. (1999) Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP. EMBO J 18(12):3359-69 |
| abstractText | In animals and several cellular models of synaptic plasticity, long-lasting changes in synaptic strength are dependent on gene transcription and translation. Here we demonstrate that Pim-1, a serine/threonine kinase closely related to Pim-2 and Pim-3, is induced in hippocampus in response to stimuli that evoke long-term potentiation (LTP). Mice deficient for Pim-1 show normal synaptic transmission and short-term plasticity. However, they fail to consolidate enduring LTP even though Pim-2 and Pim-3 are constitutively expressed in the hippocampus and Pim-3 expression is similarly induced by synaptic activity. Thus, expression of Pim-1 is required for LTP. Its level of expression and, consequently, its capacity to phosphorylate target proteins in dendritic and nuclear compartments of stimulated neurons might be a determining factor for the establishment of long-lasting changes in synaptic strength. |
