| First Author | Gong YX | Year | 2010 |
| Journal | Neurosci Lett | Volume | 468 |
| Issue | 2 | Pages | 115-9 |
| PubMed ID | 19879332 | Mgi Jnum | J:156896 |
| Mgi Id | MGI:4421635 | Doi | 10.1016/j.neulet.2009.10.079 |
| Citation | Gong YX, et al. (2010) Morphine induces conditioned place preference behavior in histidine decarboxylase knockout mice. Neurosci Lett 468(2):115-9 |
| abstractText | Pharmacological and lesion studies have shown that histamine exerts inhibitory effects on morphine-induced reward-seeking behavior. The present study was designed to further investigate the involvement of endogenous histamine in morphine-induced reward-seeking behavior using histidine decarboxylase gene knockout (HDC-KO) mice. Conditioned place preference (CPP) was present in both wild-type (WT) and HDC-KO mice treated with 5 or 10 mg/kg morphine. HDC-KO mice showed stronger morphine-induced CPP as compared with WT mice. Meanwhile, morphine significantly increased dopamine level in the VTA and NAc, especially in HDC-KO mice. However, the extinction of CPP is similar between WT and HDC-KO mice. Moreover, naloxone-precipitated withdrawal jumping was markedly decreased in HDC-KO mice. These results indicate that endogenous histamine inhibits the development, but not the extinction, of morphine-induced CPP and reduces morphine withdrawal sign, probably through modulating dopaminergic activity in the brain. |
