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Publication : GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination.

First Author  Liedtke W Year  1996
Journal  Neuron Volume  17
Issue  4 Pages  607-15
PubMed ID  8893019 Mgi Jnum  J:77630
Mgi Id  MGI:2182192 Doi  10.1016/s0896-6273(00)80194-4
Citation  Liedtke W, et al. (1996) GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. Neuron 17(4):607-15
abstractText  To investigate the structural role of glial fibrillary acidic protein (GFAP) in vivo, mice carrying a null mutation in GFAP were generated. In 7/14 mutant animals older than 18 months of age, hydrocephalus associated with white matter loss was detected. Mutant mice displayed abnormal myelination including the presence of actively myelinating oligodendrocytes in adults, nonmyelinated axons in optic nerve, and reduced myelin thickness in spinal cord. White matter was poorly vascularized and the blood-brain barrier was structurally and functionally impaired. Astrocytic structure and function were abnormal, consisting of shortened astrocytic cell processes, decreased septation of white matter, and increased CNS extracellular space. Thus, GFAP expression is essential for normal white matter architecture and blood-brain barrier integrity, and its absence leads to late-onset CNS dysmyelination.
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