| First Author | Lounnas N | Year | 2013 |
| Journal | Cancer Lett | Volume | 333 |
| Issue | 1 | Pages | 76-88 |
| PubMed ID | 23348702 | Mgi Jnum | J:196887 |
| Mgi Id | MGI:5490164 | Doi | 10.1016/j.canlet.2013.01.020 |
| Citation | Lounnas N, et al. (2013) Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas. Cancer Lett 333(1):76-88 |
| abstractText | The membrane-bound carbonic anhydrase isoforms CAIX and CAXII, underpin a pH-regulating system that enables hypoxic tumor cell survival. Here, we observed for the first time an upregulation of CAXII in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LL) cells. First we showed that CAXII is overexpressed in thymocytes from tPTEN-/- mice suffering of T lymphoma and that its pharmacological inhibition decreased cell proliferation and induced apoptosis. The same results were observed with the SupT1 human T cell lymphoma line. In addition we observed an upregulation of CAXII in human T-ALL samples supporting the case that CAXII may represent a new therapeutic target for T-ALL/LL. |
