| First Author | Yang YL | Year | 1995 |
| Journal | EMBO J | Volume | 14 |
| Issue | 24 | Pages | 6095-106 |
| PubMed ID | 8557029 | Mgi Jnum | J:30617 |
| Mgi Id | MGI:78120 | Doi | 10.1002/j.1460-2075.1995.tb00300.x |
| Citation | Yang YL, et al. (1995) Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J 14(24):6095-106 |
| abstractText | Double-stranded RNA-dependent protein kinase (PKR) has been implicated in interferon (IFN) induction, antiviral response and tumor suppression. We have generated mice devoid of functional PKR (Pkr%). Although the mice are physically normal and the induction of type I IFN genes by poly(I).poly(C) (pIC) and virus is unimpaired, the antiviral response induced by IFN-gamma and pIC was diminished. However, in embryo fibroblasts from Pkr knockout mice, the induction of type I IFN as well as the activation of NF-kappa B by pIC, were strongly impaired but restored by priming with IFN. Thus, PKR is not directly essential for responses to pIC, and a pIC-responsive system independent of PKR is induced by IFN. No evidence of the tumor suppressor activity of PKR was demonstrated. |
